What does the term "opioid tolerance" refer to?

Opioid tolerance refers to the physiological adaptation that occurs when a patient regularly uses opioids, resulting in the need for larger doses to achieve the same analgesic effect that was initially obtained with smaller doses. Over time, the body's receptors become less sensitive to the drug, which means that without an increase in dosage, patients may find that the pain relief they once experienced diminishes. Understanding this concept is crucial in pain management, as it helps healthcare providers make informed decisions about dosage adjustments and the potential need for alternative pain management strategies when tolerance develops. This physiological response differs from addiction, which entails compulsive use and psychological dependence.